The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 88 kDa).
FunctionMay play a role in junctional plaques.
Tissue specificityDetected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
Involvement in diseaseFamilial arrhythmogenic right ventricular dysplasia 9
Sequence similaritiesBelongs to the beta-catenin family. Contains 8 ARM repeats.
Cellular localizationNucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.