Anti-Plakophilin 2/PKP2 antibody (ab189323)
Key features and details
- Goat polyclonal to Plakophilin 2/PKP2
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-Plakophilin 2/PKP2 antibody
See all Plakophilin 2/PKP2 primary antibodies -
Description
Goat polyclonal to Plakophilin 2/PKP2 -
Host species
Goat -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rabbit, Horse, Hamster, Cow, Dog, Gorilla, Bat -
Immunogen
Synthetic peptide corresponding to Human Plakophilin 2/PKP2 aa 100-200 (internal sequence) (Cysteine residue). (NP_001005242.2; NP_004563.2).
Database link: Q99959 -
Positive control
- Human prostate tissue; Mouse and Rat heart lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab189323 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 97 kDa.
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IHC-P |
Use a concentration of 3.75 µg/ml.
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Notes |
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WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 97 kDa. |
IHC-P
Use a concentration of 3.75 µg/ml. |
Target
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Function
May play a role in junctional plaques. -
Tissue specificity
Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. -
Involvement in disease
Familial arrhythmogenic right ventricular dysplasia 9 -
Sequence similarities
Belongs to the beta-catenin family.
Contains 8 ARM repeats. -
Cellular localization
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes. - Information by UniProt
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Database links
- Entrez Gene: 537784 Cow
- Entrez Gene: 486613 Dog
- Entrez Gene: 101150898 Gorilla
- Entrez Gene: 101830795 Hamster
- Entrez Gene: 100070065 Horse
- Entrez Gene: 5318 Human
- Entrez Gene: 67451 Mouse
- Entrez Gene: 100347738 Rabbit
see all -
Alternative names
- ARVD 9 antibody
- ARVD9 antibody
- PKP 2 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (3)
ab189323 has been referenced in 3 publications.
- Gross A et al. Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury. Cell Mol Gastroenterol Hepatol 13:1181-1200 (2022). PubMed: 34929421
- Vallverdú-Prats M et al. Premature Termination Codon in 5' Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation. Int J Mol Sci 23:N/A (2022). PubMed: 35054841
- Zhang Z et al. Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation. Cardiology 145:136-147 (2020). PubMed: 32007997