Anti-Plasma Kallikrein 1B antibody (ab116517)

Overview

  • Product nameAnti-Plasma Kallikrein 1B antibody
    See all Plasma Kallikrein 1B primary antibodies
  • Description
    Rabbit polyclonal to Plasma Kallikrein 1B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 507-537 of Human Plasma Kallikrein 1B (NP_000883.2).

  • Positive control
    • K562 cell line lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab116517 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab116517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 71 kDa.

Target

  • FunctionThe enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
  • Involvement in diseaseDefects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
  • Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Fletcher factor antibody
    • kallikrein B plasma antibody
    • Kallikrein B plasma (Fletcher factor) 1 antibody
    • Kallikrein B, plasma 1 antibody
    • Kininogenin antibody
    • KLK3 antibody
    • KLKB1 antibody
    • KLKB1_HUMAN antibody
    • Plasma kallikrein antibody
    • Plasma kallikrein B1 antibody
    • Plasma kallikrein light chain antibody
    • Plasma prekallikrein antibody
    • PPK antibody
    • Prekallikrein antibody
    see all

Anti-Plasma Kallikrein 1B antibody images

  • Anti-Plasma Kallikrein 1B antibody (ab116517) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 71 kDa

References for Anti-Plasma Kallikrein 1B antibody (ab116517)

ab116517 has not yet been referenced specifically in any publications.

Product Wall

Following up my previous message, the immunogen for ab116517 is in fact contained within the light chain sequence. (I asked for the homology to be checked using the sequence below, UniProt P14272 aa 391-638).

IVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGS...

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The alignment of the immunogen for ab116517, Anti-Plasma Kallikrein 1B antibody, with the rat protein gives the following:

Identities = 11/15 (73%), Positives = 12/15 (80%), Gaps = 0/15 (0%)

The lab neglected to tell me whether th...

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I will send the alignment results for ab116517, hopefully later today.

I am glad ab1006 is working, at least with human samples. If you have time, we encourage our customers to send us reviews of their results, positive or negative, via our ...

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This is frustrating for us too, finding incorrect information on our datasheets. We try to minimize it but there is clearly work to be done.

I did not realize you had already purchased the antibody. If you would still like to try it with rat...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"