• Product nameAnti-Plastin L antibody
    See all Plastin L primary antibodies
  • Description
    Rabbit polyclonal to Plastin L
  • Tested applicationsSuitable for: WB, IP, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to the C terminal of Human Plastin L protein.

  • Positive control
    • HL60 cell lysate. Mouse spleen lysate. HL60 cells.



Our Abpromise guarantee covers the use of ab83496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.
IHC-P Use at an assay dependent concentration.


  • FunctionActin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
  • Tissue specificityDetected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells.
  • Sequence similaritiesContains 2 actin-binding domains.
    Contains 4 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
  • Post-translational
    Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.
    The N-terminus is blocked.
  • Cellular localizationCytoplasm > cytoskeleton. Cell junction. Cell projection. Cell projection > ruffle membrane. Relocalizes to the immunological synapse between peripheral blood T lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation.
  • Information by UniProt
  • Database links
  • Alternative names
    • CP64 antibody
    • L plastin antibody
    • L-plastin antibody
    • Larval cuticle protein 1 antibody
    • LC64P antibody
    • LCP-1 antibody
    • LCP1 antibody
    • LPL antibody
    • Lplastin antibody
    • Lymphocyte cytosolic protein 1 antibody
    • Plastin 2 antibody
    • Plastin-2 antibody
    • PLS2 antibody
    • PLSL_HUMAN antibody
    see all

Anti-Plastin L antibody images

  • All lanes : Anti-Plastin L antibody (ab83496) at 1/500 dilution

    Lane 1 : HL60 cell lysate
    Lane 2 : Mouse spleen lysate

    Predicted band size : 70 kDa
    Observed band size : 70 kDa
  • ab83496 at a 1/200 dilution, staining Plastin L in HL60 cells.

References for Anti-Plastin L antibody (ab83496)

This product has been referenced in:
  • Bouraï M  et al. Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol 86:3121-34 (2012). WB . Read more (PubMed: 22258240) »
  • Toro EJ  et al. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J Biol Chem 287:17894-904 (2012). WB . Read more (PubMed: 22474295) »

See all 2 Publications for this product

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