Overview

  • Product name
  • Description
    Rabbit polyclonal to PLC-delta-3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 59-89 of Human PLC-delta-3 (NP_588614.1).

  • Positive control
    • Mouse liver tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab123668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 89 kDa.

Target

  • Function
    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
  • Tissue specificity
    Present in corneal epithelial cells (at protein level).
  • Sequence similarities
    Contains 1 C2 domain.
    Contains 3 EF-hand domains.
    Contains 1 PH domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
  • Domain
    The C2 domain is a Ca(2+)-dependent membrane-targeting module.
    The PH domain mediates interaction with the surface membrane by binding to PIP2.
  • Cellular localization
    Membrane. Cytoplasm. Cleavage furrow. Localizes at the cleavage furrow during cytokinesis.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1-phosphatidylinositol-4 antibody
    • 5-bisphosphate phosphodiesterase delta-3 antibody
    • Phosphoinositide phospholipase C-delta-3 antibody
    • Phospholipase C-delta-3 antibody
    • PLC-delta-3 antibody
    • PLCD3 antibody
    • PLCD3_HUMAN antibody
    see all

Images

  • Anti-PLC-delta-3 antibody (ab123668) at 1/100 dilution + Mouse liver tissue lysates at 35 µg

    Predicted band size : 89 kDa

References

ab123668 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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