The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Post-translational modificationsPhosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.
Immunohistochemical analysis of PLCG 2 (phospho Y753) expression in paraffin embedded human breast carcinoma tissue using 1/50 ab55273. Left: untreated sample. Right: sample treated with immunising phosphopeptide.
References for Anti-PLCG 2 (phospho Y753) antibody (ab55273)
has not yet been referenced specifically in any publications.
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