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Rabbit monoclonal [EPR11213] to PLCL1
IP more details Unsuitable for:
Recombinant fragment corresponding to Human PLCL1.
Jurkat cell lysate; fetal brain, fetal kidney and fetal lung cell lysates; Jurkat cells.
This product is a recombinant rabbit monoclonal antibody.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
Shipped at 4°C. Store at -20ºC.
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10000 - 1/50000. Predicted molecular weight: 123 kDa.
1/100 - 1/500.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
1/100 - 1/250.
1/10 - 1/100.
Is unsuitable for IHC-P.
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
Contains 1 C2 domain.
Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.
Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1.
Information by UniProt
Inactive phospholipase C-like protein 1 antibody
Inactive protein 1 antibody
Phospholipase C deleted in lung carcinoma antibody
Immunoprecipitation - Anti-PLCL1 antibody [EPR11213] (ab157200)
Western blot analysis of Immunoprecipitation pellet from Human fetal brain lysate showing PLCL1, using ab157200 at 1/10 dilution for IP.
Western blot - Anti-PLCL1 antibody [EPR11213] (ab157200)
All lanes : Anti-PLCL1 antibody [EPR11213] (ab157200) at 1/10000 dilution Lane 1 : Human fetal brain lysate Lane 2 : Human fetal kidney lysate Lane 3 : Human fetal lung lysate Lane 4 : Jurkat lysate Lysates/proteins at 10 µg per lane. Predicted band size: 123 kDa
Immunocytochemistry/ Immunofluorescence - Anti-PLCL1 antibody [EPR11213] (ab157200)
Immunofluorescence analysis of Jurkat cells, labeling PLCL1 using ab157200 at a 1/100 dilution.
Flow Cytometry - Anti-PLCL1 antibody [EPR11213] (ab157200)
Flow cytometry analysis of permeabilized Jurkat cells labeling PLCL1 (red), using ab157200 at a 1/100 dilution, and negative control cells probed with a Rabbit IgG (green)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"