Overview

  • Product name
  • Description
    Rabbit polyclonal to PLD6
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Cow, Dog, Human
  • Immunogen

    Synthetic peptide within Human PLD6 aa 132-162 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q8N2A8

  • Positive control
    • Mouse testis lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab170183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 28 kDa.

Target

  • Function
    Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
  • Tissue specificity
    Widely expressed. Expression is not limites to testis and ovary.
  • Sequence similarities
    Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
    Contains 1 PLD phosphodiesterase domain.
  • Domain
    In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site (PubMed:17028579).
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Choline phosphatase 6 antibody
    • Mitochondrial cardiolipin hydrolase antibody
    • Mitochondrial phospholipase antibody
    • MitoPLD antibody
    • Phosphatidylcholine hydrolyzing phospholipase D6 antibody
    • Phosphatidylcholine-hydrolyzing phospholipase D6 antibody
    • Phospholipase D family member 6 antibody
    • Phospholipase D6 antibody
    • PLD 6 antibody
    • pld6 antibody
    • PLD6_HUMAN antibody
    • Protein zucchini homolog antibody
    • ZUC antibody
    • Zucchini, Drosophila, homolog of antibody
    see all

Images

  • Anti-PLD6 antibody (ab170183) at 1/100 dilution + mouse testis lysate at 35 µg

    Predicted band size : 28 kDa

References

This product has been referenced in:
  • Zhou Q  et al. Establishment of a proteome profile and identification of molecular markers for mouse spermatogonial stem cells. J Cell Mol Med 19:521-34 (2015). IF . Read more (PubMed: 25352495) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab170183.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up