• Product name
  • Description
    Rabbit polyclonal to PLEKHO1
  • Host species
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    an 18 amino acid peptide from near the carboxy terminus of human PLEKHO1 (NP_057358).

  • Positive control
    • Human lung tissue lysate



Our Abpromise guarantee covers the use of ab91489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
    • Tissue specificity
      Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cancer cell lines such as MOLT-4, HEK293 and Jurkat cells.
    • Sequence similarities
      Contains 1 PH domain.
    • Post-translational
      C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
    • Cellular localization
      Cell membrane. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • C-Jun-binding protein antibody
      • Casein kinase 2-interacting protein 1 antibody
      • CK2 interacting protein 1 antibody
      • CK2 interacting protein 1 HQ0024c protein antibody
      • CK2-interacting protein 1 antibody
      • CKIP 1 antibody
      • CKIP-1 antibody
      • CKIP1 antibody
      • JBP antibody
      • OC120 antibody
      • Osteoclast maturation associated gene 120 protein antibody
      • Osteoclast maturation-associated gene 120 protein antibody
      • PH domain-containing family O member 1 antibody
      • PKHO1_HUMAN antibody
      • Pleckstrin homology domain containing family O member 1 antibody
      • Pleckstrin homology domain-containing family O member 1 antibody
      • PLEKHO1 antibody
      see all


    • All lanes : Anti-PLEKHO1 antibody (ab91489) at 1 µg/ml

      All lanes : Human lung tissue lysate

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 46 kDa


    ab91489 has not yet been referenced specifically in any publications.

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