Overview

  • Product name
  • Description
    Rabbit polyclonal to Plexin A1
  • Tested applications
    Suitable for: WB, ELISA, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Plexin A1 aa 182-200.
    Sequence:

    RLMANEEDADMFGFVYQDE

  • Positive control
    • Cos 7 cells transfected with mouse Plexin A1 or neonatal rat brain.

Properties

Applications

Our Abpromise guarantee covers the use of ab23391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 195 kDa.
ELISA 1/2000.
IP 1/50 - 1/200.
ICC/IF 1/200. (see Abreview).

Target

  • Relevance
    Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Tissue specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.
  • Cellular localization
    Cell Membrane
  • Database links
  • Alternative names
    • NOV antibody
    • NOV/plexin A1 protein antibody
    • NOVP antibody
    • Plexin-A1 antibody
    • Plexin1 antibody
    • PlexinA1 antibody
    • PLXA1_HUMAN antibody
    • PLXN1 antibody
    • Plxna1 antibody
    • PLXNA1 protein antibody
    • Semaphorin receptor NOV antibody
    see all

Images



  • Predicted band size : 195 kDa

References

This product has been referenced in:
  • Delloye-Bourgeois C  et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci 18:36-45 (2015). Read more (PubMed: 25485759) »
  • Hernandez-Enriquez B  et al. Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing. Genes Dev 29:2617-32 (2015). Read more (PubMed: 26680304) »

See all 8 Publications for this product

Customer reviews and Q&As

Thank you for contacting us. For ab23391, the blocking peptide is ab42757. For ab25999, the blocking peptide is ab42770. If you have any other questions, please do not hesitate to contact us.

Thank you for your enquiry. This antibody was tested for Plexin-A1 reactivity using transfected cells. It was not tested against other Plexin family members. However, the immunogen was chosen based on low homology to other family members. The only s...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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