Overview

  • Product name
    Anti-PLGF antibody [RM0010-8F09]
    See all PLGF primary antibodies
  • Description
    Rat monoclonal [RM0010-8F09] to PLGF
  • Specificity
    ab51654 recognizes mouse PLGF.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant full length protein (Mouse)

Properties

Applications

Our Abpromise guarantee covers the use of ab51654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/400 - 1/1000. Predicted molecular weight: 25 kDa.

Target

  • Function
    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
  • Tissue specificity
    While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
  • Sequence similarities
    Belongs to the PDGF/VEGF growth factor family.
  • Domain
    Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
  • Information by UniProt
  • Database links
  • Alternative names
    • D12S1900 antibody
    • Pgf antibody
    • PGFL antibody
    • PIGF antibody
    • Placenta growth factor antibody
    • Placental growth factor antibody
    • Placental growth factor, vascular endothelial growth factor related protein antibody
    • PlGF 2 antibody
    • PlGF antibody
    • PLGF_HUMAN antibody
    • PlGF2 antibody
    • SHGC 10760 antibody
    see all

Images

  • ab51654 at 1/100 dilution, staining PLGF in LPS exposed mouse lung tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

References

This product has been referenced in:
  • Li Y  et al. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice. Nutrients 7:6425-45 (2015). WB ; Mouse . Read more (PubMed: 26247969) »
  • Saad AF  et al. Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia. Reprod Sci 21:138-45 (2014). Mouse . Read more (PubMed: 23749761) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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