Overview

  • Product name
  • Description
    Rabbit polyclonal to PLOD3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 85-113 of Human PLOD3 (NP_001075.1)

  • Positive control
    • MDA-MB435 cell line lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab113038 was purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab113038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 85 kDa.

Target

  • Function
    Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
  • Involvement in disease
    Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known as bone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. The syndrome is characterized by congenital malformations severely affecting many tissues and organs and revealing features of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest that the failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is the molecular basis of this syndrome.
  • Sequence similarities
    Contains 1 Fe2OG dioxygenase domain.
  • Cellular localization
    Rough endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2-oxoglutarate 5-dioxygenase 3 antibody
    • bone protein I antibody
    • BP-I antibody
    • LH3 antibody
    • Lysine hydroxylase 3 antibody
    • Lysyl hydroxylase 3 antibody
    • Plod3 antibody
    • PLOD3_HUMAN antibody
    • Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor antibody
    • Procollagen-lysine antibody
    see all

Images

  • Anti-PLOD3 antibody (ab113038) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 85 kDa

References

ab113038 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab113038.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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