Overview

  • Product name(±)-Anatoxin A fumarate
  • Description
    Potent nicotinic agonist
  • Biological descriptionPotent nicotinic agonist. Neurotoxic alkaloid produced by the cyanobacterium Anabaena flos-aquae. KI values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors in rat brain, respectively.

    Also available in simple stock solutions (ab146699) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 98%

Properties

    References for (±)-Anatoxin A fumarate (ab120013)

    This product has been referenced in:
    • Sharples CG  et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci 20:2783-91 (2000). Read more (PubMed: 10751429) »
    • Stolerman IP  et al. Behavioural effects of anatoxin, a potent nicotinic agonist, in rats. Neuropharmacology 31:311-4 (1992). Read more (PubMed: 1630597) »
    • Zhang X  et al. Anatoxin-a a potent ligand for nicotinic cholinergic receptors in rat brain. Eur J Pharmacol 135:457-8 (1987). Read more (PubMed: 3582504) »

    See 1 Publication for this product

    Product Wall

    The C4H4O4 needs to be taken into consideration when calculating concentration but it is a solubility aid first and foremost.

    We have measured the optical rotation of this material (c = 1, methanol) and the result was 0º confirming that this is a racemic mixture; this is consistent for all batches. This confirms a 50:50 mixture.

    This is a racemic mixture: 50% (+)-Anatoxin A fumarate, 50% (-)-Anatoxin A fumarate and all batches are racemic with the same ratio of (+)-Anatoxin A fumarate and (-)-Anatoxin A fumarate.

    The stereocentres are at carbons 1 and 6 on the 9-azabi...

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    ab120013 is the racemic mixture. The fumarate salt causes the compound to become water soluble.

    The molecular weight of ab120013 anatoxin A fumarate is 281.31 and its in the fumarate salt form.



    La présence de 2 pics a également été observée en HPLC lors de la détermination de la pureté du produit. Le lot de ab120013 que vous avez reçu a passé les controles qualité...

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    Veuillez trouver ci-joint le chromatogramme HPLC du produit ab120013 (asc-013).


    Lecomposé a été solubilisé dans l'eau, la longueur d'onde est de 230nm.

    J'espère que ces informations vous ser...

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    Mon collègue du laboratoire suggère de chauffer légèrement la solution (à 0.5mg/ml)et delapasser au bain à ultrason.

    Merci pour votre appel et votre patience.

    Comme je viens de vous confirmer au téléphone, le laboratoire me confirm d'essayer de passer ce produit au bains aux ultrasons. Il est mieux de ne pas chauffer le produit, car, comme vous avez dit, l...

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    Thank you for contacting us.

    I have contacted the laboratory in regards to this compound and am happy to confirm the following:

    Wecan confirm that this compound can be solubilised in Acetonitrile to 1mg per ml. As abcam biochemical...

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    1-10 of 11 Abreviews or Q&A

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"