Biological descriptionPotent L-type Ca2+ channel activator (EC50 = 17.3 nM). Centrally active following systemic administration.
Chemical name1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Samantaray S et al. Calcium channel agonist, (+/-)-Bay K8644, causes a transient increase in striatal monoamine oxidase activity in Balb/c mice. Neurosci Lett342:73-6 (2003).
Read more (PubMed: 12727321) »
Bourson A et al. Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur J Pharmacol160:339-47 (1989).
Read more (PubMed: 2469593) »
Rae GA & Calixto JB Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens. Br J Pharmacol96:333-40 (1989).
Read more (PubMed: 2466518) »