Biological descriptionSelective β1 antagonist (Ki = 22.4 nM). Antihypertensive agent.
Chemical name1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM, in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for (±)-Bisoprolol hemifumarate (ab120783)
This product has been referenced in:
de Man FS et al. Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail5:97-105 (2012).
Read more (PubMed: 22157723) »
Hoffmann C et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol369:151-9 (2004).
Read more (PubMed: 14730417) »
Schnabel P et al. Binding properties of beta-blockers at recombinant beta1-, beta2-, and beta3-adrenoceptors. J Cardiovasc Pharmacol36:466-71 (2000).
Read more (PubMed: 11026647) »
Smith C & Teitler M Beta-blocker selectivity at cloned human beta 1- and beta 2-adrenergic receptors. Cardiovasc Drugs Ther13:123-6 (1999).
Read more (PubMed: 10372227) »