Overview

  • Product name
  • Description
    Goat polyclonal to PMCA1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    C-KQDGAIENRNKAKAQD

    , corresponding to internal sequence amino acids 312-327 of Human PMCA1 (NP_001001323.1; NP_001673.2.).

  • Positive control
    • HeLa lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab126859 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 139 kDa.

Target

  • Function
    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
  • Tissue specificity
    Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver.
  • Sequence similarities
    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
  • Domain
    The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AT2B1_HUMAN antibody
    • ATP2B1 antibody
    • ATPase Ca++ transporting plasma membrane 1 antibody
    • Plasma membrane calcium ATPase 1 antibody
    • Plasma membrane calcium ATPase isoform 1 antibody
    • Plasma membrane calcium pump isoform 1 antibody
    • Plasma membrane calcium transporting ATPase 1 antibody
    • Plasma membrane calcium-transporting ATPase 1 antibody
    • PMCA 1 antibody
    • PMCA1 antibody
    see all

Images

  • Anti-PMCA1 antibody (ab126859) at 0.03 µg/ml + HeLa lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 139 kDa


    Exposure time : 1 hour

References

ab126859 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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