Overview

  • Product nameAnti-PMM2 antibody
    See all PMM2 primary antibodies
  • Description
    Rabbit polyclonal to PMM2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-184 of Human PMM2.

  • Positive control
    • HeLa and HepG2 whole cell lysates; 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab96399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 28 kDa.

Target

  • FunctionInvolved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • PathwayNucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
  • Involvement in diseaseDefects in PMM2 are the cause of congenital disorder of glycosylation type 1A (CDG1A) [MIM:212065]; also known as carbohydrate-deficient glycoprotein syndrome type Ia (CDGS1A) or Jaeken syndrome. Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1A is an autosomal recessive disorder characterized by a severe encephalopathy with axial hypotonia, abnormal eye movement, and pronounced psychomotor retardation, as well as peripheral neuropathy, cerebellar hypoplasia, and retinitis pigmentosa. Patients show a peculiar distribution of subcutaneous fat, nipple retraction, and hypogonadism.
  • Sequence similaritiesBelongs to the eukaryotic PMM family.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI585868 antibody
    • BOS_22465 antibody
    • C86848 antibody
    • CDG 1 antibody
    • CDG1 antibody
    • CDG1a antibody
    • CDGS antibody
    • MGC127449 antibody
    • Phosphomannomutase 2 antibody
    • PMM 2 antibody
    • Pmm2 antibody
    • PMM2_HUMAN antibody
    see all

Anti-PMM2 antibody images

  • All lanes : Anti-PMM2 antibody (ab96399) at 1/1000 dilution

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 28 kDa

References for Anti-PMM2 antibody (ab96399)

ab96399 has not yet been referenced specifically in any publications.

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