Anti-PMP22 antibody, prediluted (ab15507)

Overview

  • Product nameAnti-PMP22 antibody, prediluted
    See all PMP22 primary antibodies
  • Description
    Rabbit polyclonal to PMP22, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).

  • Positive control
    • Pancreas

Properties

Applications

Our Abpromise guarantee covers the use of ab15507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Working dilution, ready to use for 10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 minutes, followed by cooling at RT for 20 minutes.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMight be involved in growth regulation, and in myelinization in the peripheral nervous system.
    • Involvement in diseaseDefects in PMP22 are the cause of Charcot-Marie-Tooth disease type 1A (CMT1A) [MIM:118220]; also known as hereditary motor and sensory neuropathy IA. CMT1A is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1A inheritance is autosomal dominant.
      Defects in PMP22 are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
      Defects in PMP22 are a cause of hereditary neuropathy with liability to pressure palsies (HNPP) [MIM:162500]; an autosomal dominant disorder characterized by transient episodes of decreased perception or peripheral nerve palsies after slight traction, compression or minor traumas.
      Defects in PMP22 are the cause of Charcot-Marie-Tooth disease type 1E (CMT1E) [MIM:118300]; also known as Charcot-Marie-Tooth disease and deafness autosomal dominant. CMT1E is an autosomal dominant form of Charcot-Marie-Tooth disease characterized by the association of sensorineural hearing loss with peripheral demyelinating neuropathy.
      Defects in PMP22 may be a cause of inflammatory demyelinating polyneuropathy (IDP) [MIM:139393]. IDP is a putative autoimmune disorder presenting in an acute (AIDP) or chronic form (CIDP). The acute form is also known as Guillain-Barre syndrome.
    • Sequence similaritiesBelongs to the PMP-22/EMP/MP20 family.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CMT1A antibody
      • CMT1E antibody
      • DSS antibody
      • GAS-3 antibody
      • GAS3 antibody
      • Growth Arrest Specific 3 antibody
      • Growth arrest-specific protein 3 antibody
      • HMSNIA antibody
      • HNPP antibody
      • MGC20769 antibody
      • Peripheral myelin protein 22 antibody
      • PMP-22 antibody
      • PMP22 antibody
      • PMP22_HUMAN antibody
      • Sp110 antibody
      • Trembler antibody
      see all

    Anti-PMP22 antibody, prediluted images

    • ab15507 staining PMP22 in human pancreas by Immunohistochemistry (FFPE-sections).

    References for Anti-PMP22 antibody, prediluted (ab15507)

    ab15507 has not yet been referenced specifically in any publications.

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    Unfortunately this antibody has not been tested with mouse samples. I have checked the immunogen sequence homology, which seems to be 81% similar. So this antibody may cross react with mouse samples however as we h...

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