• Product nameAnti-PMS1 antibody
    See all PMS1 primary antibodies
  • Description
    Rabbit polyclonal to PMS1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 693-722 of Human PMS1 (NP_000525.1).

  • Positive control
    • A549 cell line lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab123883 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab123883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 106 kDa.


  • FunctionProbably involved in the repair of mismatches in DNA.
  • Involvement in diseaseDefects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3) [MIM:600258]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
  • Sequence similaritiesBelongs to the DNA mismatch repair mutL/hexB family.
    Contains 1 HMG box DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA mismatch repair protein PMS1 antibody
    • FLJ98259 antibody
    • HNPCC3 antibody
    • hPMS1 antibody
    • Human homolog of yeast mutL antibody
    • Mismatch repair gene PMSL1 antibody
    • pms1 antibody
    • PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody
    • PMS1 postmeiotic segregation increased 1 antibody
    • PMS1 protein homolog 1 antibody
    • PMS1_HUMAN antibody
    • PMSL1 antibody
    • Rhabdomyosarcoma antigen MU RMS 40.10B antibody
    • Rhabdomyosarcoma antigen MU RMS 40.10E antibody
    see all

Anti-PMS1 antibody images

  • Anti-PMS1 antibody (ab123883) at 1/100 dilution + A549 cell line lysate at 35 µg

    Predicted band size : 106 kDa

References for Anti-PMS1 antibody (ab123883)

ab123883 has not yet been referenced specifically in any publications.

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