Anti-Pneumolysin antibody (ab71811)
Key features and details
- Rabbit polyclonal to Pneumolysin
- Suitable for: WB
- Isotype: IgG
Overview
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Product name
Anti-Pneumolysin antibody
See all Pneumolysin primary antibodies -
Description
Rabbit polyclonal to Pneumolysin -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Streptococcus pneumoniae -
Immunogen
Recombinant full length protein
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.50
Constituent: 0.06% Tris buffered saline -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab71811 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use at an assay dependent dilution.
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Notes |
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WB
Use at an assay dependent dilution. |
Target
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Cellular localization
Plasma membrane -
Database links
- SwissProt: P0C2J9 Streptococcus pneumoniae
Datasheets and documents
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Datasheet download
References (9)
ab71811 has been referenced in 9 publications.
- Jacques LC et al. Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nat Commun 11:1892 (2020). PubMed: 32312961
- Panagiotou S et al. Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Sci Rep 10:17313 (2020). PubMed: 33057054
- Badgujar DC et al. Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. PLoS Pathog 16:e1009016 (2020). PubMed: 33216805
- Subramanian K et al. Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nat Microbiol 4:62-70 (2019). PubMed: 30420782
- Ye J et al. First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae. Molecules 24:N/A (2019). PubMed: 31405060
- Surve MV et al. Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking. PLoS Pathog 14:e1007168 (2018). PubMed: 30011336
- Shenoy AT et al. Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent. PLoS One 13:e0204032 (2018). PubMed: 30216364
- Liu EY et al. Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae. BMC Biotechnol 14:16 (2014). WB . PubMed: 24558977
- Brown AO et al. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog 10:e1004383 (2014). IHC-P, IHC-Fr . PubMed: 25232870