Overview

  • Product nameAnti-PNPO antibody [5]
    See all PNPO primary antibodies
  • Description
    Mouse monoclonal [5] to PNPO
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 41-261 of Human PNPO expressed in E. coli.

  • Positive control
    • HepG2 whole cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab106191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 30 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionCatalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  • PathwayCofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
    Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.
  • Involvement in diseaseDefects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
  • Sequence similaritiesBelongs to the pyridoxamine 5'-phosphate oxidase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 1.4.3.5 antibody
    • FLJ10535 antibody
    • PDXPO antibody
    • PNPO antibody
    • PNPO_HUMAN antibody
    • Pyridoxal 5' phosphate synthase antibody
    • pyridoxamine 5' phosphate oxidase antibody
    • Pyridoxamine phosphate oxidase antibody
    • Pyridoxamine-phosphate oxidase antibody
    • pyridoxine 5' phosphate oxidase antibody
    • Pyridoxine-5'-phosphate oxidase antibody
    see all

Anti-PNPO antibody [5] images

  • Anti-PNPO antibody [5] (ab106191) at 1/1000 dilution + HepG2 whole cell lysate

    Predicted band size : 30 kDa

References for Anti-PNPO antibody [5] (ab106191)

ab106191 has not yet been referenced specifically in any publications.

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