Overview

  • Product name
    PNU 120596
  • Description
    Positive allosteric modulator for the α7 nicotinic acetylcholine receptor
  • Biological description
    Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Collins T  et al. Competitive binding at a nicotinic receptor transmembrane site of two a7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. Neuropharmacology 61:1306-13 (2011). Read more (PubMed: 21820451) »
  • Livingstone PD  et al. alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex. Eur J Neurosci 29:539-50 (2009). Read more (PubMed: 19187266) »
  • Hurst RS  et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci 25:4396-405 (2005). Read more (PubMed: 15858066) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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