Overview

  • Product name
    PNU 282987
  • Description
    Selective α7 nAChR agonist
  • Biological description
    Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT3 receptors (IC50 = 4541 nM).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Vicens P  et al. Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice. Behav Brain Res 216:341-8 (2011). Read more (PubMed: 20728474) »
  • Hajós M  et al. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 312:1213-22 (2005). Read more (PubMed: 15523001) »
  • Bodnar AL  et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem 48:905-8 (2005). Read more (PubMed: 15715459) »

See 1 Publication for this product

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