Overview

  • Product name
  • Description
    Rabbit polyclonal to POLE
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal region of Human POLE.

  • Positive control
    • Human breast carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab110876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Participates in DNA repair and in chromosomal DNA replication.
  • Sequence similarities
    Belongs to the DNA polymerase type-B family.
  • Domain
    The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CRCS12 antibody
    • DKFZp434F222 antibody
    • DNA polymerase epsilon catalytic subunit A antibody
    • DNA polymerase epsilon catalytic subunit antibody
    • DNA polymerase II subunit A antibody
    • DPOE1_HUMAN antibody
    • EC 2.7.7.7 antibody
    • FILS antibody
    • FLJ21434 antibody
    • POLE antibody
    • POLE1 antibody
    • Polymerase (DNA directed) epsilon antibody
    • polymerase (DNA directed), epsilon, catalytic subunit antibody
    see all

Anti-POLE antibody images

  • ab110876, at a 1/50 dilution, staining POLE in paraffin embedded Human breast carcinoma tissue by Immunohistochemistry, in the absence (left panel) or presence (right panel) of the immunizing peptide.

References for Anti-POLE antibody (ab110876)

This product has been referenced in:
  • Elsayed FA  et al. Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. Eur J Hum Genet N/A:N/A (2014). Read more (PubMed: 25370038) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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