Overview

  • Product name
  • Description
    Rabbit polyclonal to POLG2
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the C-terminal region of human POLG2 conjugated to KLH.

  • Positive control
    • K562 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab82860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
ELISA 1/1000.

Target

  • Function
    Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
  • Involvement in disease
    Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA directed DNA polymerase gamma 2 antibody
    • DNA polymerase gamma accessory 55 kDa subunit antibody
    • DNA polymerase subunit gamma 2, mitochondrial antibody
    • DNA polymerase subunit gamma-2 antibody
    • DPOG2_HUMAN antibody
    • HP55 antibody
    • mitochondrial antibody
    • Mitochondrial DNA polymerase accessory subunit antibody
    • Mitochondrial DNA polymerase subunit gamma 2 antibody
    • Mitochondrial polymerase gamma 2 antibody
    • MtPolB antibody
    • OTTMUSP00000003758 antibody
    • p55 antibody
    • PEOA4 antibody
    • POLB antibody
    • PolG beta antibody
    • PolG-beta antibody
    • POLG2 antibody
    • POLGB antibody
    • Polymerase (DNA directed), gamma 2, accessory subunit antibody
    • Polymerase, gamma 2 antibody
    • RP23-247J12.3 antibody
    see all

Images

  • Anti-POLG2 antibody (ab82860) at 1/50 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 55 kDa
    Observed band size : 55 kDa
    Additional bands at : 100 kDa,37 kDa. We are unsure as to the identity of these extra bands.

References

ab82860 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab82860.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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