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Products:Microbiology >> Interspecies Interaction >> Host Virus Interaction
Overview
Product name
Anti-Poliovirus Receptor antibody [D171]
See all Poliovirus Receptor products (6) ...
Description
Mouse monoclonal [D171] to Poliovirus Receptor
Tested applications
Flow Cyt, Functional Studies, IFmore details
Cross reactivity
Reacts with
Human, Monkey
Does not react with
Mouse, Rat, Rabbit, Hamster, Dog, Pig
Immunogen
HeLa cells.
Epitope
Amino acids 35 - 50.
Positive control
HeLa, SV 80, HEp-2, RD, A431, HL-60 or U-937 cells.
General notes
Molecular weight of PVR = 60 - 80 kDa.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
D171
Isotype
IgG1
Research areas
Microbiology >> Interspecies Interaction >> Host Virus Interaction
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3142 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use at an assay dependent dilution. (PubMed: 16297863)
FuncS: Use at an assay dependent dilution. (This antibody protects HeLa cells against thecytopathic effect of all three poliovirus serotypes. Intact Ig or Fab fragment of this antibody prevents binding of 35S-labeled poliovirus to HeLa cells.)
IF: Use at an assay dependent dilution.
Application notes
Is unsuitable for or WB.
Target
Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Sequence similarities
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP15151
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
see all
Database links
- Entrez Gene: 5817 Human
- Omim: 173850 Human
- SwissProt: P15151 Human
- Unigene: 171844 Human
References for Anti-Poliovirus Receptor antibody [D171] (ab3142)
This product has been referenced in:
- Cain JWet al. Identification of CD44 as a surface biomarker for drug resistance by surface proteome signature technology. Mol Cancer Res 9:637-47 (2011). WB; Human.Read more (PubMed: 21357442) »
- Ogbomo Het al. Tumor cells infected with oncolytic influenza A virus prime natural killer cells for lysis of resistant tumor cells. Med Microbiol Immunol 199:93-101 (2010).Read more (PubMed: 20012989) »
See all 7 publications for this product
Publishing research using ab3142? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"