Anti-Poliovirus Receptor antibody [D171] (Biotin) (ab79434)


  • Product nameAnti-Poliovirus Receptor antibody [D171] (Biotin)
    See all Poliovirus Receptor primary antibodies
  • Description
    Mouse monoclonal [D171] to Poliovirus Receptor (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: Flow Cyt, ICC/IFmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human, Monkey
    Does not react with: Mouse, Rat, Rabbit, Hamster, Dog, Pig
  • Immunogen

    Tissue/ cell preparation (Human) - HeLa cells

  • EpitopeAmino acids 35-50
  • Positive control
    • HeLa, SV 80, HEp2, RD, A431, HL60, U937, Monkey Vero, GMK, or TC7 cells.
  • General notes

    This antibody protects HeLa cells against the cytopathic effect of all three poliovirus serotypes. Intact Ig or Fab fragment prevents binding of 35S-labeled poliovirus to HeLa cells.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.2% BSA, 10mM PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurified from ascites fluid
  • Primary antibody notesThis antibody protects HeLa cells against the cytopathic effect of all three poliovirus serotypes. Intact Ig or Fab fragment prevents binding of 35S-labeled poliovirus to HeLa cells.
  • ClonalityMonoclonal
  • Clone numberD171
  • IsotypeIgG1
  • Research areas


Our Abpromise guarantee covers the use of ab79434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionMediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
    • Sequence similaritiesBelongs to the nectin family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD155 antibody
      • CD155 antigen antibody
      • FLJ25946 antibody
      • HVED antibody
      • mE4 antibody
      • NECL 5 antibody
      • Necl-5 antibody
      • Necl5 antibody
      • Nectin like 5 antibody
      • Nectin like protein 5 antibody
      • Nectin-like protein 5 antibody
      • Ortholog of mouse Tage4 antibody
      • Poliovirus receptor antibody
      • PVR antibody
      • PVR_HUMAN antibody
      • PVS antibody
      • Taa1 antibody
      • Tage 4 antibody
      • TAGE4 antibody
      see all

    References for Anti-Poliovirus Receptor antibody [D171] (Biotin) (ab79434)

    ab79434 has not yet been referenced specifically in any publications.

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