Anti-Polo like kinase kinase (phospho S482 + S486 + S490) antibody (ab30565)

Overview

  • Product nameAnti-Polo like kinase kinase (phospho S482 + S486 + S490) antibody
  • Description
    Rabbit polyclonal to Polo like kinase kinase (phospho S482 + S486 + S490)
  • SpecificitySpecific for the PLKK protein phosphorylated at serines 482, 486 and 490.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Xenopus laevis
  • Immunogen

    Phosphopeptide corresponding to amino acid residues surrounding the phosphorylation sites Ser 482,486 and 490 of Xenopus polo-like kinase kinase (PLKK).

  • Positive control
    • Xenopus oocyte lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab30565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 120 kDa (predicted molecular weight: 112 kDa).

Target

  • RelevancePolo-like kinase (PLK) plays an important role in cell cycle regulation. It is required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a polo-like kinase kinase (PLKK) that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.
  • Cellular localizationNuclear
  • Alternative names
    • Polo like kinase kinase 1 antibody
    • Serine/threonine kinase 10 antibody
    • stk10 a antibody
    • xPlkk1 antibody

References for Anti-Polo like kinase kinase (phospho S482 + S486 + S490) antibody (ab30565)

ab30565 has not yet been referenced specifically in any publications.

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