Anti-Polycystin 1 antibody (ab118354)

Overview

  • Product nameAnti-Polycystin 1 antibody
    See all Polycystin 1 primary antibodies
  • Description
    Goat polyclonal to Polycystin 1
  • Specificityab118354 is expected to recognize both reported isoforms (NP_001009944.2; NP_000287.3).
  • Species reactivity

    Predicted to work with: Mouse, Rat, Horse, Dog, Human, Pig
  • Immunogen

    Synthetic peptide:

    KSYDPNLEDGDQT

    with a Cysteine residue linker, corresponding to amino acids 2281-2292 of Human Polycystin 1, isoform 2 (NP_001009944.2; NP_000287.3).

Properties

Applications

  • Application notesIs unsuitable for WB.
  • Target

    • FunctionMay be an ion-channel regulator. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Involved in adhesive protein-protein and protein-carbohydrate interactions.
    • Involvement in diseaseDefects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1) [MIM:173900]. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000.
    • Sequence similaritiesBelongs to the polycystin family.
      Contains 1 C-type lectin domain.
      Contains 1 GPS domain.
      Contains 1 LDL-receptor class A domain.
      Contains 2 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
      Contains 17 PKD domains.
      Contains 1 PLAT domain.
      Contains 1 REJ domain.
      Contains 1 WSC domain.
    • DomainThe LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Autosomal dominant polycystic kidney disease 1 protein antibody
      • Autosomal dominant polycystic kidney disease protein 1 antibody
      • nPKC-D1 antibody
      • nPKC-mu antibody
      • OTTHUMP00000208669 antibody
      • OTTHUMP00000208670 antibody
      • PBP antibody
      • Pc-1 antibody
      • PKD antibody
      • Pkd1 antibody
      • PKD1_HUMAN antibody
      • Polycystic Kidney Disease 1 antibody
      • polycystic kidney disease-associated protein antibody
      • Polycystin 1 Precursor antibody
      • Polycystin-1 antibody
      • Protein kinase C mu type antibody
      • Protein kinase D antibody
      • Serine/threonine-protein kinase D1 antibody
      • transient receptor potential cation channel, subfamily P, member 1 antibody
      • TRPP1 antibody
      see all

    References for Anti-Polycystin 1 antibody (ab118354)

    ab118354 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for contacting us.

    Yes, the a.a. region from 2281 - 2292 isn't really C-terminal, it's more internal. I have since removed that note from the online datasheet, but it will take a few days to refresh. Thank you for pointing that out...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"