Overview

  • Product nameAnti-Polycystin 2 antibody
    See all Polycystin 2 primary antibodies
  • Description
    Mouse monoclonal to Polycystin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PVSKTEKTNF KTLSSMEDFW KFTEGSLLDG LYWKMQPSNQ TEADNRSFIF YENLLLGVPR IRQLRVRNGS CSIPQDLRDE IKECYDVYSV SSEDRAPFGP , corresponding to amino acids 261-361 of Human Polycystin 2

Properties

Applications

Our Abpromise guarantee covers the use of ab55600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
    • Tissue specificityStrongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
    • Involvement in diseaseDefects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:613095]. ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy.
    • Sequence similaritiesBelongs to the polycystin family.
      Contains 1 EF-hand domain.
    • DomainThe C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1.
    • Cellular localizationMembrane. Endoplasmic reticulum.
    • Information by UniProt
    • Database links
    • Alternative names
      • APKD2 antibody
      • Autosomal dominant polycystic kidney disease type II antibody
      • Autosomal dominant polycystic kidney disease type II protein antibody
      • MGC138466 antibody
      • MGC138468 antibody
      • PC 2 antibody
      • PC2 antibody
      • PKD 2 antibody
      • PKD2 antibody
      • PKD2_HUMAN antibody
      • PKD4 antibody
      • Polycystic kidney disease 2 (autosomal dominant) antibody
      • Polycystic kidney disease 2 antibody
      • Polycystic kidney disease 2 protein antibody
      • Polycystin 2 antibody
      • Polycystin 2 transient receptor potential cation channel antibody
      • Polycystin-2 antibody
      • Polycystin2 antibody
      • Polycystwin antibody
      • R48321 antibody
      • Transient receptor potential cation channel subfamily P member 2 antibody
      • TRPP2 antibody
      see all

    Anti-Polycystin 2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab55600 Polycystin 2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Polycystin 2 antibody (ab55600)

    ab55600 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"