Overview

  • Product nameAnti-Polycystin 2 antibody
    See all Polycystin 2 primary antibodies
  • Description
    Rabbit polyclonal to Polycystin 2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to C-terminal residues of mouse Polycystin 2.

Properties

Applications

Our Abpromise guarantee covers the use of ab55947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 110 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • FunctionFunctions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
  • Tissue specificityStrongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
  • Involvement in diseaseDefects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:613095]. ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy.
  • Sequence similaritiesBelongs to the polycystin family.
    Contains 1 EF-hand domain.
  • DomainThe C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1.
  • Cellular localizationMembrane. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • APKD2 antibody
    • Autosomal dominant polycystic kidney disease type II antibody
    • Autosomal dominant polycystic kidney disease type II protein antibody
    • MGC138466 antibody
    • MGC138468 antibody
    • PC 2 antibody
    • PC2 antibody
    • PKD 2 antibody
    • PKD2 antibody
    • PKD2_HUMAN antibody
    • PKD4 antibody
    • Polycystic kidney disease 2 (autosomal dominant) antibody
    • Polycystic kidney disease 2 antibody
    • Polycystic kidney disease 2 protein antibody
    • Polycystin 2 antibody
    • Polycystin 2 transient receptor potential cation channel antibody
    • Polycystin-2 antibody
    • Polycystin2 antibody
    • Polycystwin antibody
    • R48321 antibody
    • Transient receptor potential cation channel subfamily P member 2 antibody
    • TRPP2 antibody
    see all

Anti-Polycystin 2 antibody images

  • Anti-Polycystin 2 antibody (ab55947) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Predicted band size : 110 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)

References for Anti-Polycystin 2 antibody (ab55947)

ab55947 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab55947.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"