Overview

  • Product namePolymyxin B peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab85004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

  • Purity70 - 90% by HPLC.
    purified
  • FormLyophilised
  • Additional notesab85007 was expressed by fermentation of Bacillus polymyxa. The peptide was subsequently purified by HPLC.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • ReconstitutionReconstitute the vial with distilled or deionized water, volume depending on the concentration to be used. After reconstitution store stock solution in aliquots at -20°C.

General Info

  • Alternative names
    • PMB
  • RelevanceThe peptide antibiotic Polymyxin B (PMB) binds to bacterial endotoxin (lipopolysaccharide, LPS). The interaction of PMB with LPS involves ionic forces between amino groups in PMB and negatively charged phosphate and carboxyl groups in the lipid A-Kdo region. PMB has relevance for endotoxin research in at least two ways: first, PMB reacts with LPS of many species regardless of varied serospecificity, and thus it can be used as a general probe for measuring or detecting LPS or lipid A. Second, binding of PMB to LPS may result in neutralization of the detrimental effects of LPS either in vitro or in vivo.
  • Cellular localizationSecreted

References for Polymyxin B peptide (ab85004)

ab85004 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"