Anti-POMT2 antibody - C-terminal (ab173085)

Overview

  • Product name
    Anti-POMT2 antibody - C-terminal
  • Description
    Rabbit polyclonal to POMT2 - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human POMT2 aa 539-567 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UKY4

  • Positive control
    • MDA-MB453 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab173085 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

Target

  • Function
    Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
  • Tissue specificity
    Highly expressed in testis; detected at low levels in most tissues.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A2 (MDDGA2) [MIM:613150]: An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Muscular dystrophy-dystroglycanopathy congenital with mental retardation B2 (MDDGB2) [MIM:613156]: An autosomal recessive disorder characterized by congenital muscular dystrophy associated with mental retardation and mild structural brain abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Muscular dystrophy-dystroglycanopathy limb-girdle C2 (MDDGC2) [MIM:613158]: An autosomal recessive muscular dystrophy with onset after ambulation is achieved. MDDGC2 is characterized by increased serum creatine kinase and mild muscle weakness. Muscle biopsy shows dystrophic changes, inflammatory changes, and severely decreased alpha-dystroglycan. Cognition is normal. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the glycosyltransferase 39 family.
    Contains 3 MIR domains.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A830009D15Rik antibody
    • AW046274 antibody
    • DKFZp686G10254 antibody
    • Dolichyl phosphate mannose protein mannosyltransferase 2 antibody
    • Dolichyl-phosphate-mannose--protein mannosyltransferase 2 antibody
    • FLJ22309 antibody
    • LGMD2N antibody
    • MDDGA2 antibody
    • MDDGB2 antibody
    • MDDGC2 antibody
    • POMT 2 antibody
    • Pomt2 antibody
    • POMT2_HUMAN antibody
    • Protein O mannosyltransferase 2 antibody
    • Protein O mannosyltransferase antibody
    • Protein O-mannosyl-transferase 2 antibody
    • Putative protein O mannosyltransferase antibody
    • rCG_20643 antibody
    see all

Images

  • Anti-POMT2 antibody - C-terminal (ab173085) at 1/100 dilution + MDA-MB453 cell line lysate at 35 µg

    Predicted band size : 84 kDa

References

ab173085 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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