Anti-PON1 antibody [EPR2892] (ab92466)


  • Product nameAnti-PON1 antibody [EPR2892]
    See all PON1 primary antibodies
  • Description
    Rabbit monoclonal [EPR2892] to PON1
  • Tested applicationsSuitable for: WB, IP, IHC-Pmore details
    Unsuitable for: ICC
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues near the N terminus of Human PON1.

  • Positive control
    • WB: plasma cells and ovary carcinoma lysate; IHC-P: liver tissue.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Associated products


Our Abpromise guarantee covers the use of ab92466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. The use of an HRP/AP polymerized secondary antibody is recommended.
    IP: 1/10 - 1/100.
    WB: 1/1000 - 1/10000. Predicted molecular weight: 40 kDa.

    Is unsuitable for ICC.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
    • Tissue specificityPlasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
    • Involvement in diseaseGenetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
    • Sequence similaritiesBelongs to the paraoxonase family.
    • Post-translational
      The signal sequence is not cleaved.
      Present in two forms, form B contains a disulfide bond, form A does not.
    • Cellular localizationSecreted > extracellular space.
    • Information by UniProt
    • Database links
    • Alternative names
      • A esterase 1 antibody
      • A-esterase 1 antibody
      • Aromatic esterase 1 antibody
      • Arylesterase 1 antibody
      • Arylesterase B type antibody
      • ESA antibody
      • Esterase A antibody
      • K 45 antibody
      • K-45 antibody
      • MVCD5 antibody
      • Paraoxonase 1 antibody
      • Paraoxonase antibody
      • Paraoxonase B type antibody
      • Paraoxonase, plasma antibody
      • Paraoxonase1 antibody
      • PON 1 antibody
      • PON antibody
      • PON1 antibody
      • PON1_HUMAN antibody
      • Serum aryldiakylphosphatase antibody
      • Serum aryldialkylphosphatase 1 antibody
      • Serum paraoxonase/arylesterase 1 antibody
      see all

    Anti-PON1 antibody [EPR2892] images

    • All lanes : Anti-PON1 antibody [EPR2892] (ab92466) at 1/1000 dilution

      Lane 1 : Human plasma cell lysate
      Lane 2 : ovarian cancer lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 40 kDa
    • ab92466, at 1/100 dilution, staining PON1 in formalin-fixed, paraffin-embedded Human liver tissue.
    • ab92466 showing negative staining in Skeletal muscle tissue.

    • ab92466 showing negative staining in Normal colon tissue.

    • ab92466 showing negative staining in Normal breast tissue.

    • ab92466 showing negative staining in Normal brain tissue.

    References for Anti-PON1 antibody [EPR2892] (ab92466)

    ab92466 has not yet been referenced specifically in any publications.

    Product Wall

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