Overview

  • Product name
    Anti-PON1 antibody [EPR2893]
    See all PON1 primary antibodies
  • Description
    Rabbit monoclonal [EPR2893] to PON1
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

  • Positive control
    • Human fetal kidney, ovary cancer, fetal liver and plasma lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Applications

Our Abpromise guarantee covers the use of ab126597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function
      Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
    • Tissue specificity
      Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
    • Involvement in disease
      Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
    • Sequence similarities
      Belongs to the paraoxonase family.
    • Post-translational
      modifications
      Glycosylated.
      The signal sequence is not cleaved.
      Present in two forms, form B contains a disulfide bond, form A does not.
    • Cellular localization
      Secreted > extracellular space.
    • Information by UniProt
    • Database links
    • Alternative names
      • A esterase 1 antibody
      • A-esterase 1 antibody
      • Aromatic esterase 1 antibody
      • Arylesterase 1 antibody
      • Arylesterase B type antibody
      • ESA antibody
      • Esterase A antibody
      • K 45 antibody
      • K-45 antibody
      • MVCD5 antibody
      • Paraoxonase 1 antibody
      • Paraoxonase antibody
      • Paraoxonase B type antibody
      • Paraoxonase, plasma antibody
      • Paraoxonase1 antibody
      • PON 1 antibody
      • PON antibody
      • PON1 antibody
      • PON1_HUMAN antibody
      • Serum aryldiakylphosphatase antibody
      • Serum aryldialkylphosphatase 1 antibody
      • Serum paraoxonase/arylesterase 1 antibody
      see all

    Images

    • All lanes : Anti-PON1 antibody [EPR2893] (ab126597) at 1/10000 dilution

      Lane 1 : Fetal kidney lysate
      Lane 2 : Ovary cancer lysate
      Lane 3 : Fetal liver lysate
      Lane 4 : Human plasma lysates

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size : 40 kDa
      Observed band size : 40 kDa

    References

    This product has been referenced in:
    • Huang Y  et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest 123:3815-28 (2013). IP ; Human . Read more (PubMed: 23908111) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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