Overview

  • Product name
  • Description
    Goat polyclonal to PON2
  • Specificity
    This antibody is expected to recognize isoforms 1 and 2 (NP_000296.2; NP_001018171.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Dog, Pig
  • Immunogen

    Synthetic peptide:

    EKPRARELRIS

    by a Cysteine residue linker, corresponding to internal sequence amino acids 93-103 of Human PON2 (NP_000296.2; NP_001018171.1)

  • Positive control
    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 39 kDa).

Target

  • Function
    Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
  • Tissue specificity
    Widely expressed with highest expression in liver, lung, placenta, testis and heart.
  • Sequence similarities
    Belongs to the paraoxonase family.
  • Post-translational
    modifications
    The signal sequence is not cleaved.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A esterase 2 antibody
    • A-esterase 2 antibody
    • Aromatic esterase 2 antibody
    • Paraoxonase 2 antibody
    • Paraoxonase nirs antibody
    • PON 2 antibody
    • PON2 antibody
    • PON2_HUMAN antibody
    • Serum aryldialkylphosphatase 2 antibody
    • Serum paraoxonase/arylesterase 2 antibody
    see all

Images

  • Anti-PON2 antibody (ab99550) at 1 µg/ml (incubation time 1 hour) + HepG2 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 39 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.

References

ab99550 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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