Overview

  • Product nameAnti-PP1C gamma antibody
    See all PP1C gamma primary antibodies
  • Description
    Rabbit polyclonal to PP1C gamma
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Rhesus monkey, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 280-323 (GAMMSVDETL MCSFQILKPA EKKKPNATRP VTPPRGMITK QAKK) of Human PP1C gamma (NP_002701.1).

  • Positive control
    • Human breast carcinoma, ovarian carcinoma, prostate carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab93864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris EDTA pH 9.0 buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProtein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
    • Sequence similaritiesBelongs to the PPP phosphatase family. PP-1 subfamily.
    • Cellular localizationCytoplasm. Nucleus. Nucleus > nucleolus. Nucleus > nucleoplasm. Nucleus speckle. Chromosome > centromere > kinetochore. Cleavage furrow. Midbody. Colocalizes with SPZ1 in the nucleus (By similarity). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase.
    • Information by UniProt
    • Database links
    • Alternative names
      • PP 1G antibody
      • PP-1G antibody
      • PP1C antibody
      • PP1G antibody
      • PP1G_HUMAN antibody
      • PP1gamma antibody
      • PPP 1G antibody
      • PPP1CC antibody
      • PPP1G antibody
      • Protein phosphatase 1, catalytic subunit, gamma isozyme antibody
      • Protein phosphatase 1C catalytic subunit antibody
      • Serine/threonine phosphatase 1 gamma antibody
      • Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody
      • Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody
      see all

    Anti-PP1C gamma antibody images

    • ab93864, at a 1/250 dilution, staining PP1C gamma in formalin fixed, paraffin embedded Human brest carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

    References for Anti-PP1C gamma antibody (ab93864)

    ab93864 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"