SpecificityThis antibody will detect all isoforms of the PP2A B subunit or also known as the Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit.
The immunogen sequence is 100% identical to Q16537; epsilon isoform (PPP2R5E), Q13362; gamma isoform (PPP2R5C), Q14738; delta isoform (PPP2R5D) and Q15173 beta isoform (PPP2R5B), and 92% identical to Q15172; alpha isoform (PPP2R5A).
Synthetic peptide corresponding to Human PP2A B subunit aa 352-365 conjugated to Keyhole Limpet Haemocyanin (KLH). The sequence is also 100% identical to Q13362 (PPP2R5C), Q14738 (PPP2R5D) and Q15173 (PPP2R5B), and 92% identical to Q15172 (PPP2R5A). Sequence:
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 56 kDa.
RelevanceSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. There is an alpha isoform, a beta isoform, a gamma isoform, a delta isoform and an epsilon isoform.