The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
FunctionMay regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Tissue specificityExpressed only in the heart, brain, and skeletal muscle.
Sequence similaritiesBelongs to the liprin family. Liprin-alpha subfamily. Contains 3 SAM (sterile alpha motif) domains.
DomainThe N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
Cellular localizationCytoplasm. Cell surface. Colocalizes with PTPRF at the cell surface.
Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 4 antibody
Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 4 antibody
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4 antibody
PTPRF interacting protein alpha 4 antibody
PTPRF-interacting protein alpha-4 antibody
Anti-PPFIA4 antibody images
Western blot - PPFIA4 antibody (ab56339)
Western blot against tagged recombinant protein immunogen using ab56339 PPFIA4 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-PPFIA4 antibody (ab56339)
This product has been referenced in:
Kiok K et al. Liprin-a4 Is Required for Nickel Induced Receptor Protein Tyrosine Phosphatase-Leukocyte Antigen Related Receptor F (RPTP-LAR) Activity. PLoS One6:e22764 (2011).
Read more (PubMed: 21829649) »