Overview

  • Product nameAnti-PPP1R3A antibody
    See all PPP1R3A primary antibodies
  • Description
    Rabbit polyclonal to PPP1R3A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide: MEPSEVPSQI SKDNFLEVPN LSDSLCEDEE VTFQPGFSPQ PSRRGSDSSE, corresponding to a region within N terminal amino acids 1-50 of Human PPP1R3A (NP_002702).

  • Positive control
    • THP1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 126 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionSeems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
  • Tissue specificitySkeletal muscle and heart.
  • Involvement in diseaseDiabetes mellitus, non-insulin-dependent
  • Sequence similaritiesContains 1 CBM21 (carbohydrate binding type-21) domain.
  • DomainThe CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
  • Post-translational
    modifications
    Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle antibody
    • Glycogen associated regulatory subunit of protein phosphatase 1 antibody
    • GM antibody
    • PP1G antibody
    • PPP1R3 antibody
    • PPP1R3A antibody
    • PPR3A_HUMAN antibody
    • Protein phosphatase 1 glycogen-associated regulatory subunit antibody
    • Protein phosphatase 1 glycogen-targeting subunit, muscle antibody
    • Protein phosphatase 1 regulatory subunit 3A antibody
    • Protein phosphatase 1 regulatory subunit GM antibody
    • protein phosphatase 1, regulatory (inhibitor) subunit 3A antibody
    • Protein phosphatase 1, regulatory subunit 3 antibody
    • Protein phosphatase type-1 glycogen targeting subunit antibody
    • RG1 antibody
    • Serine /threonine specific protein phosphatase antibody
    • Type 1 protein phosphatase skeletal muscle glycogen targeting subunit antibody
    see all

Anti-PPP1R3A antibody images

  • Anti-PPP1R3A antibody (ab104986) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 126 kDa

References for Anti-PPP1R3A antibody (ab104986)

ab104986 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"