Overview

  • Product nameAnti-PPP1R3B antibody
    See all PPP1R3B primary antibodies
  • Description
    Rabbit polyclonal to PPP1R3B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 40-89 (LSSKNEASGM VAPAVQEKKV KKRVSFADNQ GLALTMVKVF SEFDDPLDMP) of Human PPP1R3B (NP_078883).

  • Positive control
    • MCF7 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab116642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionActs as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
  • Tissue specificityHighly expressed in liver. Expressed moderately in skeletal muscle and myotubes (at protein level). Expressed predominantly in heart and skeletal muscle. Expressed moderately in liver. Expressed weakly in placenta, lung and kidney.
  • Sequence similaritiesContains 1 CBM21 (carbohydrate binding type-21) domain.
  • DomainThe N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ14005 antibody
    • FLJ34675 antibody
    • GL antibody
    • Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody
    • Hepatic glycogen targeting subunit G(L) antibody
    • Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody
    • PP1 subunit R4 antibody
    • Ppp1r3b antibody
    • PPP1R4 antibody
    • PPR3B_HUMAN antibody
    • Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody
    • Protein phosphatase 1 regulatory subunit 3B antibody
    • Protein phosphatase 1 regulatory subunit 4 antibody
    • Protein phosphatase 1 subunit 4 antibody
    • Protein phosphatase 1 subunit GL antibody
    • PTG antibody
    • R4 antibody
    see all

Anti-PPP1R3B antibody images

  • Anti-PPP1R3B antibody (ab116642) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Predicted band size : 33 kDa

References for Anti-PPP1R3B antibody (ab116642)

ab116642 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"