Overview

  • Product nameAnti-PPP2R2B antibody
    See all PPP2R2B primary antibodies
  • Description
    Rabbit polyclonal to PPP2R2B
  • SpecificityMinimal cross reactivity against 2A/B gamma.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    GEEDIDTRKINNSF

    conjugated to KLH, corresponding to N terminal amino acids 2-14 of Rat PPP2R2B

Properties

Applications

Our Abpromise guarantee covers the use of ab16447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa.

Target

  • FunctionThe B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
  • Tissue specificityBrain.
  • Involvement in diseaseDefects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).
  • Sequence similaritiesBelongs to the phosphatase 2A regulatory subunit B family.
    Contains 7 WD repeats.
  • DomainThe N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity.
    The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. Membrane and Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2ABB_HUMAN antibody
    • B55 beta antibody
    • Beta isoform of regulatory subunit B55 protein phosphatase 2 antibody
    • MGC24888 antibody
    • PP2A B55beta antibody
    • PP2A PR55B antibody
    • PP2A subunit B B beta isoform antibody
    • PP2A subunit B B55 beta isoform antibody
    • PP2A subunit B isoform B55 beta antibody
    • PP2A subunit B isoform B55-beta antibody
    • PP2A subunit B isoform beta antibody
    • PP2A subunit B isoform PR55 beta antibody
    • PP2A subunit B isoform PR55-beta antibody
    • PP2A subunit B isoform R2 beta antibody
    • PP2A subunit B isoform R2-beta antibody
    • PP2A subunit B PR55 beta isoform antibody
    • PP2A subunit B R2 beta isoform antibody
    • Ppp2r2b antibody
    • PR2AB beta antibody
    • PR2AB55 beta antibody
    • PR2APR55 beta antibody
    • PR52B antibody
    • PR55 beta antibody
    • Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform antibody
    • Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform antibody
    • Protein phosphatase 2 regulatory subunit B antibody
    • Protein phosphatase 2 regulatory subunit B beta isoform antibody
    • SCA 12 antibody
    • SCA12 antibody
    • Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
    • Serine/threonine protein phosphatase 2A neuronal isoform antibody
    • Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
    see all

References for Anti-PPP2R2B antibody (ab16447)

ab16447 has not yet been referenced specifically in any publications.

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