Overview

  • Product name
  • Description
    Rabbit polyclonal to PPP2R5C
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 464-494 of Human PPP2R5C (NP_848701.1, NP_848702.1, NP_002710.2).

  • Positive control
    • MDA-MB231 cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

Target

  • Function
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
  • Tissue specificity
    Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
  • Sequence similarities
    Belongs to the phosphatase 2A regulatory subunit B56 family.
  • Post-translational
    modifications
    Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • Cellular localization
    Nucleus. Chromosome > centromere.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2A5G_HUMAN antibody
    • B' alpha regulatory subunit antibody
    • B56G antibody
    • KIAA0044 antibody
    • MGC23064 antibody
    • PP2A B subunit B' gamma isoform antibody
    • PP2A B subunit B56 gamma isoform antibody
    • PP2A B subunit isoform B' gamma antibody
    • PP2A B subunit isoform B''-gamma antibody
    • PP2A B subunit isoform B56-gamma antibody
    • PP2A B subunit isoform PR61-gamma antibody
    • PP2A B subunit isoform R5-gamma antibody
    • PP2A B subunit PR61 gamma isoform antibody
    • PP2A B subunit R5 gamma isoform antibody
    • Ppp2r5c antibody
    • PR61G antibody
    • Protein phosphatase 2 regulatory subunit B (B56) gamma isoform antibody
    • Protein phosphatase 2 regulatory subunit B' gamma antibody
    • Protein phosphatase 2, regulatory subunit B', gamma isoform antibody
    • Renal carcinoma antigen NY REN 29 antibody
    • Renal carcinoma antigen NY-REN-29 antibody
    • Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody
    • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody
    see all

Images

  • Anti-PPP2R5C antibody (ab116531) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 61 kDa

References

ab116531 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab116531.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up