• Product nameAnti-PPP4C antibody
    See all PPP4C primary antibodies
  • Description
    Rabbit polyclonal to PPP4C
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus)
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1 and 50 of Human PPP4C (NP_002711.1)

  • Positive control
    • Human controls: metastatic lymph node carcinoma. Breast Carcinoma, Colon Carcinoma, Laryngeal Squamous Cell Carcinoma, Linitis Plastica Stomach Cancer,Metastatic Lymph Node, Non-Small Cell Lung Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor,Prostate Carcinoma, Skin Basal Cell Carcinoma, Small Cell Lung Cancer, Stomach Adenocarcinoma,Testicular Seminoma.
      Mouse Controls: Squamous Cell Carcinoma


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab84396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProtein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
    • Sequence similaritiesBelongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
    • Cellular localizationCytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • PP X antibody
      • PP-X antibody
      • Pp4 antibody
      • PP4C antibody
      • PP4C_HUMAN antibody
      • PPH3 antibody
      • PPP4 antibody
      • ppp4c antibody
      • PPX antibody
      • protein phosphatase 4 (formerly X), catalytic subunit antibody
      • Protein phosphatase 4 catalytic subunit antibody
      • Protein phosphatase X antibody
      • protein phosphatase X, catalytic subunit antibody
      • Serine/threonine protein phosphatase 4 catalytic subunit antibody
      • Serine/threonine-protein phosphatase 4 catalytic subunit antibody
      see all

    Anti-PPP4C antibody images

    • Detection of Human PPP4C by Immunohistochemistry.
      Sample: FFPE section of Human metastatic lymph node.
      Antibody: ab84396 used at a dilution of 1/500.
      Detection: DAB.
    • Detection of Mouse PPP4C by Immunohistochemistry.
      Sample: FFPE section of Mouse squamous cell carcinoma.
      Antibody: ab84396 used at a dilution of 1/100.
      Detection: DAB staining.

    References for Anti-PPP4C antibody (ab84396)

    ab84396 has not yet been referenced specifically in any publications.

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