Overview

  • Product nameAnti-PPP6C antibody
    See all PPP6C primary antibodies
  • Description
    Rabbit polyclonal to PPP6C
  • Tested applicationsSuitable for: WB, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    AVPDSERVIPPRTTTPY

    conjugated to KLH, corresponding to amino acids 287-303 of PPP6C

  • Positive control
    • IHC-P: Human Testis tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.08% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 35 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCatalytic subunit of protein phospatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
  • Tissue specificityUbiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
  • Sequence similaritiesBelongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ92648 antibody
    • MGC12249 antibody
    • PP 6 antibody
    • PP6 antibody
    • PP6C antibody
    • PPP 6 antibody
    • PPP 6C antibody
    • PPP6 antibody
    • PPP6_HUMAN antibody
    • Ppp6c antibody
    • Protein phosphatase 6 catalytic subunit antibody
    • Serine/threonine protein phosphatase 6 antibody
    • Serine/threonine protein phosphatase catalytic subunit antibody
    • Serine/threonine-protein phosphatase 6 catalytic subunit antibody
    see all

Anti-PPP6C antibody images

  • Human Testis (formalin-fixed, paraffin-embedded) stained with ab115885 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-PPP6C antibody (ab115885)

ab115885 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in Abcam's PPP6C antibodies. Regarding ab16474 and ab115885, I have aligned the immunogen sequence with the Drosophila sequence and have found only 76% identity between the two sequences.  We would not predict that they ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"