Biological descriptionPotent, subtype selective ERα estrogen receptor agonist. Over 400-fold selective for ERα over ERβ receptors.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Roesch DM Effects of selective estrogen receptor agonists on food intake and body weight gain in rats. Physiol Behav87:39-44 (2006).
Read more (PubMed: 16181647) »
Harris HA et al. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand. Endocrinology143:4172-7 (2002).
Read more (PubMed: 12399409) »
Stauffer SR et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem43:4934-47 (2000).
Read more (PubMed: 11150164) »