• Product nameAnti-PQBP1 antibody
    See all PQBP1 primary antibodies
  • Description
    Rabbit polyclonal to PQBP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 72-121 (LVSWLSPHDP NSVVTKSAKK LRSSNADAEE KLDRSHDKSD RGHDKSDRSH) of Human PQBP1 (NP_001027555).

  • Positive control
    • OVCAR-3 cell lysate.


Associated products


Our Abpromise guarantee covers the use of ab86525 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionMay suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.
  • Tissue specificityWidely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.
  • Involvement in diseaseDefects in PQBP1 are the cause of Renpenning syndrome 1 (RENS1) [MIM:309500]; also known as Sutherland-Haan X-linked mental retardation syndrome (SHS) or X-linked mental retardation syndromes MRXS3/MRXS8/MRX55. The clinical features are mental retardation, microcephaly, short stature, and small testes. The craniofacies tends to be narrow and tall with upslanting palpebral fissures, abnormal nasal configuration, cupped ears, and short philtrum. The nose may appear long or bulbous, with overhanging columella. Less consistent manifestations include ocular colobomas, cardiac malformations, cleft palate, and anal anomalies. RENS1 is more frequently in males than in females where little or no expression is found.
  • Sequence similaritiesContains 1 WW domain.
  • DomainThe WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with C-terminal domain of RNA polymerase II large subunit.
  • Cellular localizationNucleus. Co-localized with POU3F2. Co-localized with ATXN1 in nuclear inclusion bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • 38 kDa nuclear protein containing a WW domain antibody
    • Mental retardation, X linked 55 antibody
    • MRX55 antibody
    • MRXS3 antibody
    • MRXS8 antibody
    • Npw38 antibody
    • Nuclear protein containing WW domain 38 kD antibody
    • OTTHUMP00000025808 antibody
    • Polyglutamine binding protein 1 antibody
    • Polyglutamine tract binding protein 1 antibody
    • Polyglutamine tract-binding protein 1 antibody
    • Polyglutamine-binding protein 1 antibody
    • PQBP 1 antibody
    • PQBP-1 antibody
    • PQBP1 antibody
    • PQBP1_HUMAN antibody
    • RENS1 antibody
    • SHS antibody
    • Sutherland Haan X linked mental retardation syndrome antibody
    see all

Anti-PQBP1 antibody images

  • Anti-PQBP1 antibody (ab86525) at 1 µg/ml (in 5% skim milk / PBS buffer) + OVCAR-3 cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 30 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 50 kDa. We are unsure as to the identity of these extra bands.

References for Anti-PQBP1 antibody (ab86525)

ab86525 has not yet been referenced specifically in any publications.

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