Overview

  • Product nameAnti-PR3 antibody [WGM2]
    See all PR3 primary antibodies
  • Description
    Mouse monoclonal [WGM2] to PR3
  • Tested applicationsSuitable for: WB, IHC-P, IHC-Fr, Functional Studies, Flow Cyt, Inhibition Assay, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    neutrophils(degranulated supernatant)

  • General notes


    ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation.

Properties

Applications

Our Abpromise guarantee covers the use of ab91181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10. Predicted molecular weight: 28 kDa.
IHC-P 1/10.
IHC-Fr 1/10.
Functional Studies Use at an assay dependent concentration.
Flow Cyt 1/10. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
Inhibition Assay Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.

Target

  • FunctionPolymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
  • Sequence similaritiesBelongs to the peptidase S1 family. Elastase subfamily.
    Contains 1 peptidase S1 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACPA antibody
    • AGP 7 antibody
    • AGP7 antibody
    • AGP7 serine proteinase antibody
    • Azurophil Granule Protein 7 antibody
    • C ANCA antibody
    • C ANCA antigen antibody
    • C-ANCA antigen antibody
    • CANCA antibody
    • EC 3.4.21.76 antibody
    • Leukocyte proteinase 3 antibody
    • MBN antibody
    • MBT antibody
    • MBT WEGENER AUTOANTIGEN antibody
    • Myeloblastin antibody
    • Neutrophil proteinase 4 antibody
    • NP 4 antibody
    • NP-4 antibody
    • NP4 antibody
    • P29 antibody
    • PR 3 antibody
    • PR-3 antibody
    • PR3 antibody
    • Proteinase 3 antibody
    • Proteinase3 antibody
    • PRTN 3 antibody
    • Prtn3 antibody
    • PRTN3_HUMAN antibody
    • Serine proteinase neutrophil Wegener granulomatosis autoantigen antibody
    • Serine proteinase, neutrophil antibody
    • Wegener autoantigen antibody
    • Wegener granulomatosis autoantigen antibody
    see all

References for Anti-PR3 antibody [WGM2] (ab91181)

This product has been referenced in:
  • Murakami M  et al. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS One 9:e110677 (2014). Read more (PubMed: 25330301) »
  • Xu PC  et al. Myeloperoxidase influences the complement regulatory function of modified C-reactive protein. Innate Immun N/A:N/A (2013). Human . Read more (PubMed: 24189124) »

See all 7 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"