Overview

  • Product name
  • Description
    Rabbit polyclonal to PRAME
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide from within residues: MVQAWPFTCL PLGVLMKGQH LHLETFKAVL DGLDVLLAQE VRPRRWKLQV , corresponding to N terminal amino acids 72-121 of Human PRAME (NP_006106)

  • Positive control
    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
  • Tissue specificity
    Expressed in testis. Detected in samples of kidney, brain and skin.
  • Sequence similarities
    Belongs to the PRAME family.
    Contains 4 LRR (leucine-rich) repeats.
  • Cellular localization
    Nucleus. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4930534P07Rik antibody
    • Cancer/testis antigen 130 antibody
    • CT130 antibody
    • MAPE antibody
    • Melanoma antigen preferentially expressed in tumors antibody
    • OIP 4 antibody
    • OIP-4 antibody
    • OIP4 antibody
    • OPA interacting protein 4 antibody
    • Opa interacting protein OIP4 antibody
    • OPA-interacting protein 4 antibody
    • PRAME antibody
    • PRAME_HUMAN antibody
    • Preferentially expressed antigen in melanoma antibody
    • Preferentially expressed antigen of melanoma antibody
    • RP23-250F8.3 antibody
    see all

Images

  • Anti-PRAME antibody (ab90053) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 58 kDa

References

ab90053 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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