Dopamine D2-like receptor agonist showing some selectivity for D3 (Ki values are 3.9 (D2L), 3.3 (D2S), 0.5 (D3) and 3.9 nM (D4)). Potent antioxidant. Displays antidepressant and anti-Parkinsonian effects.
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Pramipexole dihydrochloride (ab120569)
This product has been referenced in:
Newman-Tancredi A et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharmacol Exp Ther303:805-14 (2002).
Read more (PubMed: 12388667) »
Ling ZD et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther289:202-10 (1999).
Read more (PubMed: 10087005) »
Mierau J et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol290:29-36 (1995).
Read more (PubMed: 7664822) »